A Novel Potential Therapeutic Target as Adjuvant Treatment for Cancer: The Pharmacological Interference on the Ca2+/Camp Cellular Signaling Pathways
نویسندگان
چکیده
*Corresponding author: Leandro Bueno Bergantin, Department of Pharmacology, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brazil. Laboratory of Autonomic and Cardiovascular Pharmacology Rua Pedro de Toledo, 669 Vila Clementino, São Paulo SP, Brazil, CEP: 04039-032, Tel: 55 11 5576-4973; E-mail: [email protected] Citation: Errante PR, Leite AA, Menezes-Rodrigues FS, Caricati-Neto A, Bergantin LB (2017) A Novel Potential Therapeutic Target as Adjuvant Treatment for Cancer: The Pharmacological Interference on the Ca2+/Camp Cellular Signaling Pathways. Enliven: Challenges Cancer Detect Ther 2(1): e001.
منابع مشابه
The Canonical Wnt Signaling (Wnt/β-Catenin Pathway): A Potential Target for Cancer Prevention and Therapy
Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt-signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseas...
متن کاملApoptosis: from Signalling Pathways to Therapeutic Tools
Apoptosis or programmed cell death is a gene regulated phenomenon which is important in both physiological and pathological conditions. It is characterized by distinct morphological features including chromatin condensation, cell and nuclear shrinkage, membrane blebbing and oligonucleosomal DNA fragmentation. Although, two major apoptotic pathways including 1) the death receptor (extrinsic) and...
متن کاملChanges in expression of klotho affect physiological processes, diseases, and cancer
Klotho (KL) encodes a single-pass transmembrane protein and is predominantly expressed in the kidney, parathyroid glands, and choroid plexus. Genetic studies on the KL gene have revealed that DNA hypermethylation is one of the major risk factors for aging, diseases, and cancer. Besides, KL exerts anti-inflammatory and anti-tumor effects by regulating signaling pathways and the expression of tar...
متن کاملA Novel Therapeutic Target for Treatment of Alzheimer’s disease: The Ca2+/Camp Signalling Interaction
It is well recognized that an imbalance of intracellular Ca2+ homeostasis contributes to the pathogenesis of neurodegenerative diseases, such as Alzheimer’s (AD). Therefore, regulation of intracellular Ca2+ homeostasis may represent a new target for treatment of this disease. Our recent discovery of the participation of the interaction between intracellular signalling pathways mediated by Ca2+ ...
متن کاملPathway Analysis of miRNA-1 and Its Expres-sion Evaluation in Donor’s Serum from HIV-Positive Individuals vs Unaffected Controls
Background MicroRNAs (miRNAs) are non-coding RNA molecules (19-24 nucleotides) that play a major role in a wide range of biological processes through post-transcriptional regulation of gene expression. Differential expression of miRNAs has been reported in various infectious diseases such as HIV infection. The characterization of miRNA expression profiles, especially in mammalian biofluids, whi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017